Mixed linear model approach adapted for genome-wide association studies
نویسندگان
چکیده
منابع مشابه
An efficient hierarchical generalized linear mixed model for pathway analysis of genome-wide association studies
MOTIVATION In genome-wide association studies (GWAS) of complex diseases, genetic variants having real but weak associations often fail to be detected at the stringent genome-wide significance level. Pathway analysis, which tests disease association with combined association signals from a group of variants in the same pathway, has become increasingly popular. However, because of the complexiti...
متن کاملPenalized multivariate linear mixed model for longitudinal genome-wide association studies
We consider analysis of Genetic Analysis Workshop 18 data, which involves multiple longitudinal traits and dense genome-wide single-nucleotide polymorphism (SNP) markers. We use a multivariate linear mixed model to account for the covariance of random effects and multivariate residuals. We divide the SNPs into groups according to the genes they belong to and score them using weighted sum statis...
متن کاملGenetic Studies: The Linear Mixed Models in Genome-wide Association Studies
With the availability of high-density genomic data containing millions of single nucleotide polymorphisms and tens or hundreds of thousands of individuals, genetic association study is likely to identify the variants contributing to complex traits in a genome-wide scale. However, genome-wide association studies are confounded by some spurious associations due to not properly interpreting sample...
متن کاملFurther Improvements to Linear Mixed Models for Genome-Wide Association Studies
We examine improvements to the linear mixed model (LMM) that better correct for population structure and family relatedness in genome-wide association studies (GWAS). LMMs rely on the estimation of a genetic similarity matrix (GSM), which encodes the pairwise similarity between every two individuals in a cohort. These similarities are estimated from single nucleotide polymorphisms (SNPs) or oth...
متن کاملNature Methods FaST linear mixed models for genome-wide association studies
Supplementary Figure 1 Q-Q plots for the WTCCC data. Supplementary Note 1 The FaST-LMM algorithm.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 2010
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.546